Lipid Controls
Cayman Chemical DLIn-MC3-DMA 10mg
An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity
![Medchemexpress LLC Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]- | 1445832-74-5 | 99.95% | 2000 (Average) | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385579-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]- | 1445832-74-5 | 99.95% | 2000 (Average) | 25 MG
DSPE-PEG (2000)-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. This compound is capable of forming micelles for targeted drug delivery.
- Can form micelles for targeted drug delivery
- Useful for polyvalent targeted delivery of vinorelbine to cancer cells
- Can be used as optical coherence tomography contrast agents for tumor angiography in live animals
- Targets liposome
- Pathway: Metabolic enzyme/protease
- Powder stable at -20°C for 3 years
- In solvent stable at -80°C for 6 months, and at -20°C for 1 month
- Solubility in H2O: 25 mg/mL (requires ultrasonic treatment)
- Solubility in DMSO: 25 mg/mL (requires ultrasonic, warming, and heating to 60°C)
- Achieves a clear solution at ≥ 2.5 mg/mL in specific in vivo solvent combinations
- For research use only
Cayman Chemical DLIn-KC2-DMA 1mg
An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model
Cayman Chemical 1 3DIoloyl2ElaIdoyl Glyce 25mg
A triacylglycerol; has been used to study the effects of unsaturation and sn-2 substitution on the polymorphic behavior of triacylglycerols
Avanti Polar Lipids Brain Total Lipid Extract (Porcine), 86088-88-2, 100mg
Total Lipid Extract is a chloroform:methanol extract of the respective tissue (Brain, Soybean, Heart, etc.). This extract is partitioned against deionized water, and the chloroform phase is concentrated.
Avanti Polar Lipids 16:0-18:1 PG (25MG)
1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt). 268550-95-4
Medchemexpress LLC Butanoic acid, 4-(dimethylamino)-, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien... | 1224606-06-7 | 99.9% | 642.09 | 500 MG
D-Lin-MC3-DMA is an ionizable cationic lipid that serves as a potent siRNA delivery vehicle. It is intended for research use only and not for sale to patients.
- Potent siRNA delivery vehicle.
- Exhibits an optimized pKa value that leads to dramatically enhanced potency in vivo when formulated in lipid nanoparticles (LNPs) for siRNA delivery.
- Can be formulated into lipid nanoparticles with specific molar ratios for siRNA targeting transthyretin (TTR) mRNA.
- LNP-siRNA systems containing D-Lin-MC3-DMA optimize gene silencing potency in hepatocytes following IV administration in mice.
- Available in various quantities and solution formats.
Cayman Chemical 1 3DIstearoyl2oloyl Glyce 50mg
A triacylglycerol; has been found in Kpangnana, Chinese tallow, and cocoa butters; increases the phagocytic function of reticulo-endothelial cells in mice at 5 and 10 mg per animal
Medchemexpress LLC D-Lin-MC3-DMA | 1224606-06-7 | MFCD31657426 | 50 mg
D-Lin-MC3-DMA | Purity: ≥98.0% | Mol Wt: 642.102 | 1224606-06-7 | MFCD31657426 | 50 mg
eMolecules Broadpharm / 181 Lyso PC / 50mg / 779524169 / BP-29613 / / 19420-56-5 / MFCD00133435 / 521.676 / C26H52NO7P
Broadpharm / 181 Lyso PC / 50mg / 779524169 / BP-29613 / / 19420-56-5 / MFCD00133435 / 521.676 / C26H52NO7P